Understanding the heterogeneous drug response of cancer patients is essential to precision oncology.Pioneering genomic analyses of individual cancer subtypes have begun to identify key determinants of resistance, including up-regulation of multi-drug resistance (MDR) genes and mutational alterations of drug targets.However, these alterations are su
Abstract Background Karst areas in southwestern China exhibit ecological degradation in the form of rocky desertification.Local governments launched large-scale afforestation and other ecological restoration programs to curb this trend.Soil thickness is a key limiting factor for vegetation restoration in Karst areas, but the relationship between ec
Abstract Background Despite recent progress in understanding the molecular mechanisms regulating aging and lifespan, and the pathways involved being conserved in different species, a full understanding of the aging process has not been reached.In particular, increasing evidence suggests an active role for the nervous system in lifespan regulation,
The spotted sand bass (Paralabrax maculatofasciatus) is an important recreational sport and subsistence food fish within San Diego Bay, a large industrialized harbor in San Diego, California.Despite this importance, few studies examining the species life history relative to pollutant tissue concentrations and the consumptive fishery exist.This stud
Qin Tong,1,* Shuming Ouyang,2,* Lingling Feng,3,* Hanyu Wang,3 Yunfei Xia,3 Yujing Zhang3 1Department of Radiation Oncology, The First Affiliated Hospital of University of South China, Hengyang 421001, People’s Republic of China; 2Department of Obstetrics and Gynecology, The First Affiliated Hospital of University of South China, Hengyang 421